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ObvioHealth Announces Ground-Breaking Digital Therapeutics API to Capture More Accurate Efficacy and Adherence Data in Clinical Trials

ByDennis Dailey webHorse

Digital therapeutic DCTs get a tech upgrade to improve experience and accuracy

ObvioHealth, a pioneering virtual research organization, launches a proprietary application programming interface (API) tailored specifically for digital therapeutic (DTx) clinical trials. The API provides DTx sponsors with a “plug and play” integration to ObvioHealth’s ObvioGo platform, enabling the capture of more objective adherence and efficacy data while also reducing burden for clinical trial participants.

DTx clinical trials present unique challenges when it comes to measuring adherence and efficacy. To determine adherence, sponsors must consider duration and frequency of DTx use and compliance with the DTx tasks. Some clinical trials might measure these factors through patient-reported questionnaires. However, this method can bias the data because 1) declared behaviors can be inaccurate, and 2) the questionnaires can trigger a participant to use the DTx, thus influencing their real-world behaviors.

“Adherence in a DTx trial isn’t as simple as recording whether a participant took a pill or didn’t. Instead, you need to capture the level of interaction between the participant and the DTx,” said Craig Gravina, Chief Technology Officer at ObvioHealth. “This requires data to be captured directly from the source—the DTx itself—without prompts that might influence the participant’s behavior.”

ObvioHealth’s API ensures tight integration between the digital therapeutic and the ObvioGo platform, providing sponsors with accurate data to correlate efficacy with adherence to the DTx. In addition, ObvioGo’s integration reduces participant task duplication because—in most cases—outcomes can be passively captured directly from the DTx.

“Some trial partners will use separate apps to ask many of the same questions that are asked within the DTx— an annoyance for participants and an overly complicated trial design for sponsors. It’s important for sponsors to recognize these study design nuances that can have a dramatic impact on the integrity of study data and participant behavior,” said Ivan Jarry, ObvioHealth’s CEO. “ObvioGo’s solution is uniquely positioned to overcome these DTx challenges and facilitate regulatory approvals.”

ObvioHealth’s mobile app can be used for complementary tasks, such as eConsent, screening, concomitant medication recording, televisits and the reporting of potential adverse events, in addition to other non-redundant eCOA data capture. The company is currently in the design phase for four DTx studies.

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